Cellply Fringe Event: Session 1

11.15 - 11.30 am Linking In-Vitro Analysis Of Function And Phenotype For Deep Characterization Of Cell Therapy At The Single-Cell Level

• Single cell multiparametric analysis enhances understanding of immunotherapy mode of action
• Analysis of cytotoxicity and phenotype reveals immune cell functional heterogeneity, i.e. “which cells do what” and provides actionable data to support discovery and process development

Francesco Imperatore, Senior Scientist, Cellply

11.30 - 11.45am Break

11.45am - 12.00pm Measurement And Optimization Of Potency And Fitness Of Novel TCR-T Cell Therapies, Using Single-Cell Cytotoxicity Analysis.

• Frequency of serial killer cells as an indicator of enhanced T-cell fitness in novel TCR-T cells engineered with innovative DNA nanovectors.
• Evaluating the effect of donor heterogeneity and the impact of vector composition on therapeutic potency using a unified potency score

Richard Harbottle, Head of DNA Vector Research, German Cancer Research Centre